1. Content and Objectives
Mechanism of action of opioids, NSAIDS and adjuvants
Efficacy of opioids, NSAIDS and adjuvants
Analgesic equivalence
2. Required Readings
McNicol E, Strassels S, Goudas L, Lau J, Carr D. Nonsteroidal Anti-Inflammatory Drugs, Alone or combined With Opioids, for Cancer Pain: A Systematic Review. J Clin Oncol 2004;22:1975-1992.
Gammaitoni AR, Fine P, Alvarez N, McPherson ML, Bergmark S. Clinical application of opioid equianalgesic data. Clin J Pain 2003;19:286-297.
Couzin J. Clinical trials. Halt of Celebrex study threatens drug's future, other trials. Science 2004;306(5705):2170.
Dworkin RH, Backonja M, Rowbotham MC, Allen RR, et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol 2003;60:1524-34.
Cepeda MS, Carr DB, et al. Comparison of morphine, ketorolac, and their combination for postoperative pain: results from a large, randomized, double blind trial. Anesthesiology 2005;103:1225-1232.